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RSV CAN BE EASILY MISTAKEN FOR INFLUENZA1
RSV CAN BE EASILY MISTAKEN FOR INFLUENZA1
HIGHLY CONTAGIOUS3-5
HIGHLY CONTAGIOUS3-5
SEASONAL6-8
SEASONAL6-8
A COMMON CAUSE OF ACUTE RESPIRATORY INFECTION (ARI)1,3,5
A COMMON CAUSE OF ACUTE RESPIRATORY INFECTION (ARI)1,3,5
IN INFANTS AND
YOUNG CHILDREN12,13*
IN INFANTS AND
YOUNG CHILDREN12,13*
IN SOME ADULTS WITH CERTAIN RISK FACTORS14
IN SOME ADULTS WITH CERTAIN RISK FACTORS14
IN OLDER ADULTS15†
IN OLDER ADULTS15†
HEAR REAL PEOPLE SHARE HOW RSV HAS AFFECTED THEIR LIVES
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IN INFANTS AND
YOUNG CHILDREN6,25,26
IN INFANTS AND YOUNG CHILDREN, CLINICAL PRESENTATION MAY INCLUDE6,25,26
IN SOME ADULTS WITH CERTAIN RISK FACTORS27,28
IN SOME ADULTS WITH CERTAIN RISK FACTORS, CLINICAL PRESENTATION MAY INCLUDE27,28
IN OLDER ADULTS3,5
IN OLDER ADULTS, CLINICAL PRESENTATION MAY INCLUDE3,5,21
Infants can be highly susceptible to RSV due to their inability to mount innate
antiviral immune responses and because their airways are particularly vulnerable to inflammation and obstruction.3,5
of hospitalizations due to bronchiolitis3
of hospital admissions due to pneumonia3
hospitalizations29
visits to an emergency department29
visits to a primary care office29
‡Based on a 2009 study that determined the population-based burden of RSV infection among 919 hospitalized children and outpatients in emergency departments and primary care settings. The study used data from the New Vaccine Surveillance Network, a prospective, population-based inpatient and outpatient surveillance for acute respiratory infections among children under 5 years of age in 2000 in Nashville and Rochester, New York; and in 2003 in Cincinnati.29
SEASONAL INCIDENCE OF MEDICALLY ATTENDED RSV IS ~2X HIGHER FOR INFANTS
(6-11 MONTHS) THAN FOR OLDER CHILDREN (24-59 MONTHS)30§
§Based on a 2016 study that described the seasonal incidence of inpatient and outpatient medically attended RSV and influenza over multiple seasons in a community-based cohort of 2384 children aged 6 to 59 months. The study focused on children living in the central region of the Marshfield Epidemiologic Study Area (MESA), a dynamic, population-based cohort of approximately 54,000 residents living in 14 ZIP codes surrounding Marshfield, Wisconsin. Nearly all MESA residents received their medical care from Marshfield Clinic, an integrated, multispecialty healthcare system serving the MESA population.30
(1 year)13
(2-4 years)13
(5-9 years)13
(10-17 years)13
||Based on a 2021 study of the incidence of medically attended ARI due to RSV in children (≥1 year) and adults across 5 influenza seasons in Washington State (2011/2012-2015/2016).13
Chronic heart disease, COPD, asthma, and other selected comorbidities are all risk factors for severe RSV disease.14
IN A STUDY OF ADULT PATIENTS WITH CORE RISK FACTORS# FOR SEVERE RSV OR INFLUENZA INFECTIONS14:
A GREATER PROPORTION OF PATIENTS WITH RSV AND CORE RISK FACTORS REQUIRED HOSPITAL STAYS >3 DAYS COMPARED TO PATIENTS WITH INFLUENZA AND CORE RISK FACTORS14
RSV PATIENTS EXPERIENCED MORE COMPLICATIONS DURING
HOSPITALIZATION, INCLUDING LOWER RESPIRATORY COMPLICATIONS, CARDIOVASCULAR COMPLICATIONS, AND BACTERIAL SUPERINFECTIONS, COMPARED TO PATIENTS WITH INFLUENZA14
#Core risk factors included any one or a combination of the following: age ≥65 years, chronic heart disease, COPD, and asthma.14
Immunosenescence, or natural age-related immune system deterioration, can lower immune responsiveness, making older adults more susceptible to RSV infection. Even the most vital and active older adult will experience some immunosenescence as a consequence of aging.1
IN A STUDY THAT INCLUDED ADULT PATIENTS WITH RSV (INCLUDING THOSE WITH AND WITHOUT UNDERLYING CONDITIONS), OLDER ADULTS HAD WORSE OUTCOMES THAN THOSE 18 TO 49 YEARS OF AGE, INCLUDING31:
for patients aged ≥65 years compared with patients
aged 18-49 years31
for patients aged ≥65 years
compared with patients
aged 18-49 years31
for patients aged ≥65 years compared with patients
aged 18-49 years31
IN OLDER ADULTS (AGED ≥60 YEARS) WITH RSV7:
THE RISK OF HOSPITALIZATION, AN EMERGENCY DEPARTMENT VISIT, OR PNEUMONIA HAS BEEN REPORTED TO BE ~2X GREATER IN THOSE WITH OR WITHOUT COMORBIDITIES7
**Data presented above highlight the annual healthcare resource use and costs of the burden of RSV in those ≥65 years and 18-49 years. From a large observational study analyzing 11,000 patients ≥1 year (patients stratified by age group from ≥1 year to ≥85 years) with an RSV event in the US with follow-up data for 12 months.